Programme
April 26 (Sunday)
10:00-18:00 Registration, display of posters
18:00-22:00 Opening ceremony, dinner, poster viewing
April 27 (Monday)
9:00-11:00 Structure and receptors (chairs: Willie C. Russell & Glen R. Nemerow)
9:00-9:20 CryoEM structure of the human adenovirus type 2 temperature sensitive mutant 1
Phoebe L. Stewart, Mariena Silvestry, Steffen Lindert, Jason G. Smith, Christopher M. Wiethoff, Glen R. Nemerow
9:20-9:40 Localization of the N-terminus of minor coat protein IIIa in the adenovirus capsid
Carmen San Martín, Joel N. Glasgow, Anton Borovjagin, Matthew S. Beatty, Elena A. Kashentseva, David T. Curiel, Roberto Marabini, Igor P. Dmitriev
9:40-9:55 Structural analysis of adenovirus by X-ray diffraction
Vijay Reddy, Phoebe L. Stewart, Glen R. Nemerow
9:55-10:10 Crystallographic structure of a porcine adenovirus fibre containing unique galectin-like carbohydrate recognition domains
Pablo Guardado-Calvo, Antonio L. Llamas-Saiz, Gavin C. Fox, David T. Curiel, Joel N. Glasgow, Mark J. van Raaij
10:10-10:25 An arginine switch in the adenovirus knob determines engagement of the cellular receptor CD46
David Persson, Steffen Mueller, Dirk M. Reiter, Marko Marttila, Benedikt Schmitt, Nikolaus Schmitz, Christian Ochsenfeld, Niklas Arnberg, Thilo Stehle
10:25-10:45 Apical localization and unique interactions of the Coxsackievirus and Adenovirus Receptor
Katherine J. D. A. Excoffon, Nicholas D. Gansemer, Joseph Zabner
10:45-11:00 The GD1a glycan is a cellular receptor for human adenovirus type 37
Emma Nilsson, Susanne Johansson, Fariba Jamshidi, Aivar Lookene, Nahid Razi, Fatima Pedrosa-Domellöf, Jonas Ångström, Mattias Hedenström, Niklas Arnberg
11:00-11:20 coffee break
11:20-12:40 Entry & trafficking (chairs: Phoebe L. Stewart & Andrew H. Baker)
11:20-11:40 Probing adenovirus interactions with lymphocytes using quantum dot labelled virus
David Onion, Morgan Herod, Andrew Hislop, Vivien Mautner
11:40-12:00 A late domain is required for efficient adenovirus entry
Daniel Henaff, Zsolt Ruzsics, Baptist Jammart, Olivier Coux, Chris Wiethoff, Eric J. Kremer, Harald Wodrich
12:00-12:20 A new role for kinesin-1 in adenovirus capsid disassembly and disruption of the nuclear pore complex
Sten Strunze, Martin Engelke, Karin Boucke, Daniel Puntener, Sibylle Schleich, Michael Way, Philipp Schoenenberger, Christoph Burckhardt, Urs F. Greber
12:20-12:40 CAR-associated axonal transport of an adenovirus in pH-neutral vesicles
Sara Salinas, Lynsey Bilsland, Daniel Henaff, Anne E. Weston, Giampietro Schiavo, Eric J. Kremer
13:00-14:00 lunch
14:00-15:30 Replication & host cell interaction 1
(chairs: Katherine R. Spindler & David A. Matthews)
14:00-14:25 Adenovirus small e1a stimulation of cell cycling
Arnold J. Berk, Gauri Jawdekar, Gawei Dou, Roberto Ferrari, Matteo Pellegrini, Siavash Kurdistani
14:25-14:40 Human adenovirus type 5 early region 1 B 55-kDa oncoprotein is modified by different isoforms of the small ubiquitin-related modifier (SUMO)
Peter Wimmer, Sabrina Schreiner, Peter Groitl, Thomas Dobner
14:40-14:55 Intrinsic disorder in the amino terminus of human adenovirus type 5 E1B-55K and its related proteins
Timo Sieber, Roland Scholz, Michael Spörner, Hans-Robert Kalbitzer, Thomas Dobner
14:55-15:10 A 49K isoform of the adenovirus type 5 early region 1 B 55K protein is sufficient to support virus replication
Sabrina Schreiner, Kathrin Kindsmüller, Florian Leinenkugel, Peter Groitl, Elisabeth Kremmer, Thomas Dobner
15:10-15:30 Targeting PP2A to a chromatin remodeling factor by the adenovirus E4orf4 protein
Anna Brestovitsky, Rakefet Sharf, Tamar Kleinberger
15:30-16:00 coffee break
16:00-18:00 Replication & host cell interaction 2 (chairs: Arnold J. Berk & Urs F. Greber)
16:00-16:25 Shaping the ends of adenovirus DNA
Frank L. Graham
16:25-16:45 Human adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression
Susan J. Morris, Keith N. Leppard
16:45-17:00 Adenovirus L4-22K stimulates major late transcription by a mechanism requiring the intragenic late specific transcription factor-binding site
Ellenor Backström, Kerstin B. Kaufmann, Sara Östberg, Göran Akusjärvi
17:00-17:20 Human adenovirus 41 interaction with hematopoietic cells: cellular permissiveness and viral gene expression analysis
Misael Leonardo Silva, Joselma Siqueira-Silva, Fernanda Perez Yeda, Marcelo Bibancos, Charlotte M. Hársi
17:20-17:40 Proteomic analysis of adenovirus interactions with the nucleolus
Vanessa Evans, David A. Matthews
17:40-18:00 Role of adenovirus structural proteins in virus-host cell interaction
Johan Rebetz, Manli Na, Changqing Su, Niklas Arnberg, Qijun Qian, Xiaolong Fan
18:00-19:00 dinner
19:00-20:25 Epidemiology (chairs: Charlotte [Sári] Hársi & Niklas Arnberg)
19:00-19:20 Human adenovirus 14a: Update on activity and status of our knowledge about this emerging respiratory pathogen in the United States
Adriana E. Kajon, Xiaoyan Lu, David Metzgar, Dean D. Erdman
19:20-19:40 Molecular epidemiology of respiratory adenovirus epidemics in United States military recruits suggests importance of exposure history and herd immunity
David Metzgar
19:40-19:55 Outbreak of adenovirus keratoconjuntivitis in health care workers: coinfection with different adenovirus species
Marcela Echavarria, Mariana Galante, Fabian Herrera, Cristina Videla, Elena Temporiti, Thomas Lion, Guadalupe Carballal, Pablo Bonvehi
19:55-20:10 Genetic variability of human adenoviruses associated with acute respiratory disease in children from São Paulo, Brazil
Juliana C. Marinheiro; Patrícia O. Moura; Daniela Carvalho; Joselma Siqueira-Silva; Patrícia R. Sacramento; Xiaoyan Lu; Alfredo E Giglio; Sandra E Vieira; Viviane F. Botosso; Edison L. Durigon; Dean D.Erdman; Charlotte M. Hársi
20:10-20:25 Surveillance of human adenoviruses in Italian wastewater treatment plants by nested PCR and real-time PCR analyses
Michele Muscillo, Marcello Iaconelli, Manoochehr Pourshaban, Giuseppina La Rosa
20:25-22:00 Poster session
April 28 (Tuesday)
8:45-10:50 Immunology and pathogenesis (chairs: Eric J. Kremer & Hans-Gerhard Burgert)
8:45-9:05 Molecular insights into the functional relationship between the immunomodulatory E3-19K protein and the class I antigen presentation pathway
Jie Fu, Lavanya Visvabharathy, Marlene Bouvier
9:05-9:25 Importance of conserved amino acids for structure and function of the adenovirus protein E3/19K
Martina Sester, Katja Koebernick, Douglas Owen, Minghui Ao, Beatrice Menz, Hans-Gerhard Burgert
9:25-9:40 Key role of splenic myeloid DCs in the IFN-ab response to adenoviruses in vivo
György Fejér, Lisa Drechsel, Ulrike Schleicher, Zsolt Ruzsics, Nicola Imelli, Urs F. Greber, Simone Keck, Anne Krug, Christian Bogdan, Marina A. Freudenberg
9:40-10:00 Activation of a dendritic cell-T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells
Matthieu Perreau, Franck Mennechet, Hugh Welles, Giuseppe Pantaleo, Eric Kremer
10:00-10.15 Improved adenovirus-based vaccine provides enhanced protection against ebola virus infection
Jason S. Richardson, Michel K. Yao, Kaylie N. Tran, Maria A. Croyle, James E. Strong, Heinz Feldmann, Gary P. Kobinger
10:15-10:35 Defensin-mediated neutralization of adenovirus infection
Jason G. Smith, Mariena Silvestry, Phoebe L. Stewart, Glen R. Nemerow
10:50-11:00 coffee break
11:00-13:00 New developments (chairs: Marlene Bouvier & Keith N. Leppard)
11:00-11:20 Mouse adenovirus type 1-induced breakdown of the blood-brain barrier
Lisa E. Gralinski, Shanna L. Ashley, Shandee D. Dixon, Katherine R. Spindler
11:20-11:40
Characterization of murine adenovirus 1 and 2
Sandra Ramelli, Willy Decurtins, Justyna Ruminska, Urs Greber, Silvio Hemmi
11:40-12:00 New insights in the mechanism of adenovirus cell release and its modulation to enhance the antitumoral potency of oncolytic adenoviruses
Alena Gros, Ramon Alemany, Manel Cascalló
12:00-12:15 Expression of an engineered hyperfusogenic class I fusion glycoprotein in order to enhance efficacy of oncolytic adenoviral vectors
François Durupt, Olivier Terrier, Luc Thomas, Bruno Lina, Rob Hoeben, Manuel Rosa-Calatrava
12:15-12:30 Chromatographic purification of viral vectors using CIM® Convective Interaction Media technology
Barbara Lah, Marko Banjac, Petra Kramberger, Matjaž Peterka, Aleš Štrancar
12:30-11:50 Augmenting the immune response to adenovirus encoded antigens
Peter Johannes Holst, Maria Rathmann Sørensen, Cathrine Ørskov, Camilla Mandrup Jensen, Mirjana Grujic, Anette Stryhn, Christina Batholdy, Allan Randrup Thomsen, Jan Pravsgaard Christensen
13:00-14:00 lunch
14:00-15:10 Clinical applications 1 (Jadviga [Wisia] Chroboczek & Morvane Colin)
14:00-14:20 Changes in promoters activity in human laryngeal carcinoma cells resistant to vincristine are responsible for increased adenoviral transgene expression
Dragomira Majhen, Anamaria Brozović, Tvrtko Buger, Maja Osmak, Andreja Ambriović-Ristov
14:20-14:35 Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie
Martine Bruley Rosset, Antoine Sacquin, Sylvie Lecollinet, Thomas Chaigneau, Micheline Adam, François Crespeau, Marc Eloit
14:35-14:55 Oncolytic adenovirus Ad5/3-Cox2L-D24 in a treatment of cancer patients
Sari Pesonen, Petri Nokisalmi, Sophie Escutenaire, Merja Särkioja, Vincenzo Cerullo, Leena Laasonen, Kilian Guse, Elina Haavisto, Minna Oksanen, Maria Rajecki, Ari Ristimäki, Anna Kanerva, Timo Joensuu, Akseli Hemminki
14:55-15:10 New pancreatic carcinoma model for studying oncolytic adenoviruses in the permissive Syrian hamster
Jacqueline F. Spencer, John E. Sagartz, William S.M. Wold, Károly Tóth
15:10-15:40 coffee break
15:40-17:00 Clinical applications 2 (chairs: Adriana E. Kajon & G. Eric Blair)
15:40-15:55 Combining oncolytic adenoviruses with Gemcitabine as a novel treatment for pancreatic cancer
Gioia Cherubini, Stephan Leitner, Nick Lemoine, Gunnel Halldén
15:55-16:20 Safety and efficacy of oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor (GM-CSF) in advanced metastatic cancer patients
Vincenzo Cerullo, Sari Pesonen, Iulia Diaconu, Sophie Escutenaire, Mari Raki, Merja Särkioja, Laura Ahtiainen, Eerika Karli, Sirkka-Liisa Holm, Petteri T. Arstila, Lotta Kangasniemi, Kilian Guse, Petri Nokisalmi, Elina Haavisto, Aila Karioja-Kallio, Matteo Ugolini, Minna Oksanen, Timo Joensuu, Leena Laasonen, Anna Kanerva, Akseli Hemminki
16:20-16:40
The human adenovirus chimeric vector Ad5F35-CFTR efficiently corrects the CFTR
deficiency in human airway epithelia via apical transduction,
and its
cell entry pathway does not negatively
interfere with the CFTR chloride
channel function
Ophélia
Granio, Katherine J.D.A. Excoffon, Petra
Henning, Patricia Melin, Caroline Norez, Gaëlle Gonzalez,
Philip H. Karp, Maria K. Magnusson, Nagy Habib,
Leif Lindholm, Frédéric Becq, Pierre Boulanger, Joseph
Zabner, Saw-See Hong
16:40-17:00 Adenovirus dodecahedron, a drug delivery vector
Ewa Szołajska, Monika Zochowska, Guy Schoehn, Jadwiga Chroboczek
17:00-17:30 refreshments
17:30-19:00 Evolution and diversity (chairs: Andrew J. Davison & Morris Jones)
17:30-17:45 Evidence of molecular evolution driven by recombination events influencing tropism and virulence in a novel human adenovirus that causes epidemic keratoconjunctivitis
Michael P. Walsh, Ashish Chintakuntlawar, Christopher M. Robinson, Ijad Madisch, Balázs Harrach, Nolan R. Hudson, David Schnurr, Albert Heim, James Chodosh, Donald Seto, Morris S. Jones
17:45-18:00 Unique sequence features of the human adenovirus 31 prototype complete genomic sequence are conserved in clinical isolates from cases of disseminated disease
Soeren Hofmayer, Ijad Madisch, Heidi Deppe, Gabriele Harste, Albert Heim
18:00-18:15 Characterization of polymorphic subspecies B1 human adenoviruses ORF E3-10.K
Kathryn M. Frietze, Adriana E. Kajon
18:15-18:30 Studies and insights on the molecular evolution and phylogeny of adenoviruses using a combined bioinformatics and genomics approach
Padmanaban Mahdevan, Jason Seto, Gopy Kammila, Michael Walsh, Nolan R. Hudson, Sarah Torres, Morris S. Jones, Donald Seto
18:30-18:45 Genome analysis of raptor adenovirus 1: a novel, non‑isolated type, first member of a proposed new species in the genus Siadenovirus
Endre R. Kovács, Balázs Harrach, Mária Benkő
18:45-19:00 Adenoviruses flying around: search for novel adenoviruses to recognize their diversity and better understand their evolution
Balázs Harrach, Andor Doszpoly, Márton Vidovszky, Máté Jánoska, Judit Pénzes, Győző Kaján, Endre Kovács, Gabriella Skoda, Mónika Ballmann, Eszter Dandár, Mária Benkő
19:00-20:00 dinner
20:00-21:00 Discussion: How to name adenoviruses? (chairs: Marcela Echavarría & Don Seto)
20:00-22:00 Poster session
April 29 (Wednesday)
9:00-10:15 Vectors and tropism modifications; oncolytics
(chairs: Andrea Ambriovic-Ristov & David T. Curiel)
9:00-9:15 A selectively replicating adenovirus expressing the prodrug-converting enzyme CD/UPRT (Ad∆∆CU) had greatly enhanced oncolytic potency in prostate cancer cells
Maria Ekblad, Daniel Oberg, Nick Lemoine and Gunnel Halldén
9:15-9:30 Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
Morgan Herod, Ramon Alemany, Vivien Mautner, Peter Searle
9:30-9:45 Replication-competent Ad11p vector (RCAd11p) efficiently transduces and replicates in hormone-refractory metastatic prostate cancer cells
Linda Sandberg, Praveen Papareddy, Jim Silver, Anders Bergh, Ya-Fang Mei
9:45-10:00 Mutant adenovirus polymerases for bioselection of oncolytic adenoviruses
Taco G. Uil, Jort Vellinga, Jeroen de Vrij, Sanne K. van den Hengel, Martijn J.W.E. Rabelink, Steve J. Cramer, Yavuz Ariyurek, Michiel van Galen, Johan T. den Dunnen, Peter C. van der Vliet, Rob C. Hoeben
10:00-10:15 Deletion of protein IX from human adenovirus type 5 leads to enhanced virus spread and cell killing in 2D and 3D in vitro models
Jeroen de Vrij, Nicholas A. Roesen, Sanne K. van den Hengel, Danijela Koppers-Lalic, Jort Vellinga, Robert Kraaij, Kitty M. Kwappenberg, Marco W. Schilham, Vivien Mautner, Rob C. Hoeben
10:15-10:45 coffee break
10:45-12:00 Vectors and tropism modifications; capsid modifications
(chairs: Vivien Mautner & Pierre Boulanger)
10:45-11:00 Modification of Ad5 hexon ablates interaction with coagulation factor X and hepatocyte transduction
Raul Alba, Angela Bradshaw, Alan L. Parker, David Bhella, Stuart A. Nicklin, Simon N. Waddington, Jerome Custers, Jaap Goudsmit, Nico Van Rooijen, Dan H. Barouch, John H. McVey, Andrew Baker
11:00-11:15 Into and away from liver: precise modulation of the hepatocyte tropism of adenovirus-based gene transfer vectors in vivo
Florian Kreppel, Jan-Michael Prill, Sigrid Espenlaub, Tatjana Engler, Ulrike Samen, Erika Schmidt, Stefan Kochanek
11:15-11:30 The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution
Daniel Henaff, Elena Seiradake, Harald Wodrich, Olivier Billet, Matthieu Perreau, Claire Hippert, Franck Mennechet, Guy Schoehn, Hugues Lortat-Jacob, Hanna Dreja, Sandy Ibanes, Vasiliki Kalatzis, Jennifer P. Wang, Robert W. Finberg, Stephen Cusack, Eric J. Kremer
11:30-11:45 Cysteines surrounding an RGD motif inserted in the HI loop of adenovirus type 5 fiber protein influence its retargeting potential
Dragomira Majhen, Jennifer Richardson, Andreja Ambriović Ristov
11:45-12:00 Improved human adenovirus type 5 vector-mediated transduction of resistant cells by piggybacking on CAR-pseudotyped baculovirus
Ophélia Granio, Marine Porcherot, Stéphanie Corjon, Petra Henning, Leif Lindholm, Saw-See Hong, Pierre Boulanger
12:00-13:00 Poster session
13:00-14:00 lunch
14:00-15:30 Vectors and tropism modifications; disease targets
(chairs: Saw-See Hong & Akseli E. Hemminki)
14:00-14:15 A recombinant adenovirus for targeted gene therapy of inflammation
Justin C. Roth, Michael O. Alberti, Larisa Pereboeva, Svetlana Komarova, John F. McCauley, Yuko Tsuruta, Edward Abraham, Stanton L. Gerson, David T. Curiel
14:15-14:30 B7-H-1/B7-1 bridge triggers efficient gene delivery into leukemic residual cells using modified adenoviral vector
Elodie Grellier, Sophie Rogée, Katia Lécolle, Anne Loyens, Jean-Claude Beauvillain, Saw-See. Hong, Pierre Boulanger, Jean-Claude D'Halluin, Bruno Quesnel, Morvane Colin
14:30-14:45 Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid
Betsy Jullienne, Frédéric Vigant, Erika Muth, Ronan Chaligné, Céline Bouquet, Stéphane Giraudier, Michel Perricaudet, Karim Benihoud
14:45-15:00 Somatostatin receptors: relevant target for specific brain gene delivery by modified adenoviral vectors
Katia Lécolle, Séverine Bégard, Raphaëlle Caillerez, Elodie Grellier, Grosjean Marie-Eve, Anne Loyens, Jean-Claude Beauvillain, Jean-Claude D'Halluin, Luc Buée, Morvane Colin
15:00-15:15 Genetic retargeting of Ad5 using a novel class of ligands (nanobodies) belonging to the immunoglobulin superfamily and having a large natural diversity.
Leif Lindholm, Maria Magnusson, Catharina Wising, Petra Henning, Daniel Baty, Patrick Chames, Ralph Willemsen
15:15-15:30 High-capacity adenoviral vectors in gene therapy: the new generation has begun
Anja Ehrhardt, Martin Häusl, Wenli Zhang, Christina Rauschhuber, Lorenz Jäger, Raphael Liesner, Nadine Müther
15:30-16:00 coffee break
16:00-17:15 Non-HAdV based vectors for gene therapy 1
(chairs: Silvio Hemmi & Suresh K. Mittal)
16:00-16:20 Gag-specific immune enhancement of lentiviral infection after vaccination with an adenoviral vector in an animal model of AIDS
Bernard Klonjkowski, Dieter Klein, Sandra Galea, Françoise Gavard, Martine Monteil, Lidia Duarte, Annie Fournier, Sophie Sayon, Kamila Górna, Reinhard Ertl, Nathalie Cordonnier, Pierre Sonigo, Marc Eloit, Jennifer Richardson
16:20-16:40 Adenoviruses colonize the gut of non-human primates which serve as a reservoir for cross-species transmission to humans
Soumitra Roy, Luk H. Vandenberghe, Roberto Calcedo, Sergey Kryazhimskiy, Rebecca Grant, Xin Yuan, Martin Keough, Arbans Sandhu, Qiang Wang, C. Angelica Medina-Jaszek, Joshua B. Plotkin, James M. Wilson
16:40-17:00 Novel adenovirus vectors from chimpanzees: technology platform for genetic vaccine applications
Stefano Colloca
17:00-17:15 Full genome sequence analysis of a goose and a turkey aviadenovirus
Győző L. Kaján, Andrew J. Davison, Vilmos Palya, Balázs Harrach, Mária Benkő
17:15-17:30 refreshments
17:30-19:00 Non-HAdV based vectors for gene therapy 2 (chairs: Göran Wadell & Stefan Kochanek)
17:30-17:45 Engineering adenovirus genomes by BAC technology
Jens-Bernhard Lösing, Stefan Jordan, Torsten Sacher, Zsolt Ruzsics
17:45-18:00 Potential receptor usage by nonhuman adenoviruses
Suresh K. Mittal, Dinesh S. Bangari, Xiaoxin Li, Elizabeth Clark, Anurag Sharma, Manish Tandon
18:00-18:15 Genetic targeting of avian adenovirus vectors
Olga V. Zubkova, Denis Y. Logunov, Maxim M. Shmarov, Vasiliy N. Rogozhin, Boris S. Naroditsky, Alexander L. Gintsburg
18:15-19:15 Discussion on the safety issues of such vectors (moderated by the chairs)
20:00-22:30 Farewell dinner
April 30 (Thursday)
9:00-11:00 Buses leaving for Budapest city or airport terminals
Presentation instructions
The oral presentations will be performed by PowerPoint running on PC.
Please, bring your presentation on flash drive (or on CD) and handle it to our students when registering
(or at least one day before the scheduled speaking time).
Please note, that the time given in the time table means that you have to leave 5 minutes for the discussion (or 3 minutes if you are scheduled for "15" minutes. Thank you in advance for keeping the time thus ensuring the integrity of the whole program.
Posters
The preferred poster size is 70 x 100 cm and it should be "portrait" oriented. The heights can be larger (up to 120 cm) if needed.
However, if you intended to bring a previously made poster of slightly different
size it will also be accommodated.
We propose the relatively small size because the number of posters is much larger than we expected.
Poster titles
Structure and receptors
Direct and indirect in vitro interactions of wild-type and mutant adenovirions and individual adenoviral capsid proteins with heparan sulphate proteoglycans and coagulation factor X: a physico-chemical and imaging study
Stéphanie Corjon, Pascal Fender, Daphna Fenel, Karim Benihoud, Pierre Boulanger, Saw See Hong
Structural studies on adenoviruses
Céline M.S. Fabry, Majida El Bakkouri, Manuel Rosa-Calatrava, Christine Moriscot, Oliver Billet, Pascal Fender, Leandro F. Estrozi, Long Le, David T. Curiel, Andrey V. Kajava, Stephen Cusack, Eric J. Kremer, Pierre Boulanger, Rob W.H. Ruigrok, Guy Schoehn
Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK
Charlotte Farmer, Penny Morton, Marjolein Snippe, Maddy Parsons, George Santis
Characterization of Ad5 vectors encoding a unique fiber with galectin-like carbohydrate recognition domains
Pablo Guardado-Calvo, Masaharu Nakayama, David F. Smith, David T. Curiel, Mark J. van Raaij, Joel N. Glasgow
Defining the role of CD46, CD80 and CD86 in mediating Ad3 fibre interactions with host cells
Kathryn Hall, Maria E. Blair Zajdel, G. Eric Blair
Coagulation factors IX and X enhance binding and infection of human adenovirus types 5 and 31 in human epithelial cells
Mari I. Jonsson, Annasara E. Lenman, Lars Frängsmyr, Cecilia Nyberg, Mohamed Abdullahi, Niklas Arnberg
Re-targeting Ad5 vectors for efficient transduction and activation of dendritic cells in vivo
Erin E. Thacker, Masaharu Nakayama, Ann Marie O’Neill, Bruce F. Smith, R.Curtis Bird, Laura Timares, Theresa V. Strong, Zhanat Muminova, Alexander Pereboev, David T. Curiel
Entry and trafficking
Investigating the receptor requirements of human adenovirus serotype 5 (Ad5) vectors
Angela C. Bradshaw, Alan L. Parker, Simon N. Waddington, John McVey, Stuart A. Nicklin, Andrew H. Baker
Macropinocytotic uptake and infection of kidney epithelial cells with species Human adenovirus B2 type 35
Stefan Kälin, Michele Gastaldelli, Beat Amstutz, Nicole Liska, Nina Wolfrum, Menzo Havenga, Fabienne Di Gennaro, Silvio Hemmi, Urs F. Greber
Block in entry of fastidious human enteric adenovirus type 41
Tom K. H. Leung, Martha Brown
A live cell reporter of human adenovirus cores illuminates capsid disassembly prior to nuclear import of the viral genome
Daniel Püntener, Zsolt Ruzsics, Urs F. Greber
How does human adenovirus type 2 switch from microtubules to nuclear pore complexes at the nuclear envelope?
I-Hsuan Wang, Christoph Burckhardt, Martin Engelke, Matthias Morf, Urs F. Greber
Replication and host cell interaction
RNA interference-mediated inhibition of adenoviruses
Reinhard Klein, Margit Rauch, Thomas Lion
Identification of adenovirus E1A-gene regions involved in chemosensitisation of prostate cancer cells
Enrique Miranda, Nick Lemoine, Gunnel Halldén
Epidemiology
Epidemiology of epidemic keratoconjunctivitis in Japan
Koki Aoki, Hiroaki Ishiko, Shigeaki Ohno, Hisatoshi Kaneko
Spread of epidemic keratoconjunctivitis due to a novel serotype of human adenovirus in Japan
Hiroaki Ishiko, Yasushi Shimada, Tsunetada Konno, Akio Hayashi, Takeshi Ohguchi, Yoshitsugu Tagawa, Koki Aoki, Shigeaki Ohno, Hisatoshi Kaneko, Shudo Yamazaki
Immunology and pathogenesis
A naturally occurring human adenovirus type 7 variant with a 1743 bp E3 deletion
Juliana C. Marinheiro; Tatiana G. Santos; Márcio A. Padovani, Patrícia O. Moura; Daniela Carvalho; Joselma Siqueira-Silva; Xiaoyan Lu; Eurico Arruda Neto; Dean D. Erdman; Charlotte M. Hársi
Recirculating Ad5-specific CD4 T cells express α4 β7 integrins following T-cell proliferation which may enable them to home to intestinal mucosa
Matthieu Perreau, Hugh Welles, Eric Kremer, Giuseppe Pantaleo
Development of recombinant adenoviruses expressing M. tuberculosis antigens, and transfection of dendritic cells
Dmitriy N. Shcherbinin, Irina L. Tutykhina, Maxim M. Shmarov, Denis Y. Logunov, Boris S. Naroditsky, Tatiana K. Kondratieva, Alexander S. Apt
Protection against avian influenza virus H5N1 following vaccination by a porcine adenovirus vector with low seroprevalence in humans
Kaylie N Tran, Ami Patel, Michael Gray, Suresh K. Tikoo, Darwyn Kobasa, Gary P. Kobinger
Conformational epitope mapping of species Human adenovirus B and C types by phage display and molecular modeling
Laura E. Valinotto, Paola R. Barrero, Alicia S. Mistchenko
New developments
Identification of antiadenoviral activity of a small organic compound
Emma Andersson, Mårten Strand, Karin Edlund, Kristina Lindman, Yafang Mei, Göran Wadell
Optimization of capsid-incorporated antigens for an improved HIV-adenovirus vaccine approach
Qiana L. Matthews, Aiman Fatima, Yizhe Tang, Brian A. Perry, Yuko Tsuruta, Svetlana Komarova, Laura Timares, Anton V. Borovjagin, Jerry Blackwell, Phoebe L. Stewart, David T. Curiel
Effect of warfarin on biodistribution of intraperitoneal administration of adenovirus in vivo
Kellie S. Matthews, Angel A. Rivera, Ronald D. Alvarez, David T. Curiel, Meredith A. Preuss
Production of recombinant human lactoferrin in the allantoic fluid of embryonated chicken eggs and its characteristics
Irina L. Tutykhina, Olga A. Bezborodova, Maxim M. Shmarov, Denis Y. Logunov, Elena R. Nemtsova, Raisa I. Iakubovskaia, Boris S. Naroditsky, Alexander L. Gintsburg
Production of recombinant adenoviruses in HEK293 cells cultivating within wide-porous agarose cryogel scaffolds
Irina L. Tutykhina, Maxim M. Shmarov, Denis Y. Logunov, Ludmila V. Verkhovskaya, Liliya G. Damshkaln, Vladimir I. Lozinsky, Boris S. Naroditsky, Alexander L. Gintsburg
In vitro dynamic visualization analysis of fluorescently labeled minor capsid protein IX and core protein V by simultaneous detection
Hideyo Ugai, Minghui Wang, Long P. Le, David A. Matthews, Masato Yamamoto, David T. Curiel
Clinical applications
Cycles of transient immunosuppression and recovery along with multiple rounds of intratumoral injection of an oncolytic adenovirus vector: strategy for developing a clinical protocol
Debanjan Dhar, Jacqueline F. Spencer, Károly Tóth, William S.M. Wold
Retrograde
delivery of the neurotrophic factors genes into the spinal cord cells using
recombinant adenoviral vectors prolong life span
of patients with ALS
Maxim M. Shmarov,
Elena S.
Sedova,
Irina L.
Tutykhina, Ludmila V.
Verkhovskaya, Denis Y. Logunov, Nataliya A.
Suponeva, Aleksey V. Vasiliev, Lev V. Brylev, Maria N.
Zakharova, Sergey N. Illarioshkin, Viacheslav Z. Tarantul, Igor A. Zavalishin,
Boris S. Naroditsky, Alexander L. Gintsburg
Evolution and diversity
Phylogeny and primary structure analysis of all HAdV fiber shafts for rational design of adenoviral gene therapy vectors
Sebastian Darr, Ijad Madisch, Heidi Deppe, Gabriele Harste, Albert Heim
Genome analysis of fish adenovirus seems to confirm a need of establishing the fifth adenovirus genus
Andor Doszpoly, Balázs Harrach, Mária Benkő
Detection of novel simian adenoviruses and comparison with earlier isolated primate adenoviruses
Máté Jánoska, Andor Doszpoly, Győző Kaján, Laura Pantó, Balázs Harrach
Isolation and initial characterization of candidate guinea pig adenovirus (GPAdV)
Adriana Kajon, Kathryn Frietze and Susan McGrath
Analysis of human adenovirus type 22 provides evidence for recombination events between species HAdV-D in the penton base
Christopher M. Robinson, David. W. Dyer, Morris S. Jones, Jaya Rajaiya, James Chodosh
Characterisation of the murine adenovirus 2 genome and partial sequences from similar rodent adenoviruses
Márton Vidovszky, Sandra Ramelli, Willy Decurtins, Justyna Ruminska, Andor Doszpoly, Gabriella Skoda, Máté Jánoska, Balázs Harrach, Urs Greber, Silvio Hemmi
Vectors and tropism modifications
Identifying novel functions of adenoviral VAI RNA for use in cancer virotherapy
Christopher Binny, Yaohe Wang, Nicholas Lemoine
Mucosal delivery of adenoviral vectors: dependence on CD11chigh dendritic cells and subcellular localisation of antigen
Petra Henning, Tobias Gustafsson, Carl-Fredrik Flach, Anna Strömbeck, Jan Holmgren, Leif Lindholm, Ulf Yrlid
An optimal genetic method for the generation of a fiber mosaic adenoviral vector
Miho Murakami, Hidyo Ugai, Maaike Everts, Natalya Belousova, Larisa Pereboeva, Alexander Pereboev, Masato Yamamoto, David T. Curiel
Bi-directional promoter controlled Ad5F35 vector for coordinated gene transfer in human hematopoitic stem cells
Manli Na, Nivedita Naqachar, Xiaolong Fan
New viral vector for oral vaccination derived from an enteric adenovirus
Aurélie Perrin, Sandra Galea, Didier Poncet, Bernard Klonjkowski, Jennifer Richardson
Construction and biological properties of a recombinant dodecahedron containing the short fiber protein of the human adenovirus 41
Joselma Siqueira-Silva, Pascal Fender, Evelyne Gout, Fernanda P. Yeda, Misael L. Silva, Juliana Cristina Marinheiro, Charlotte M Hársi
Retargeting adenoviral vectors for improving oral vaccination
Muhammad Suleman, Sandra Galea, Françoise Gavard, C. Viarouge, Michael Barry, Eric Tartour, Blaise Corthesy, Marc Eloit, Bernard Klonjkowski, Jennifer Richardson
Derivation of a triple mosaic adenovirus for cancer gene therapy
Yizhe Tang, Hongju Wu, David T. Curiel
Mutation in the HAdV-5 i-leader causes increased cytolytic activity on malignant gliomas.
Sanne K. van den Hengel, Jeroen de Vrij, Taco G. Uil, Martine L. Lamfers, Peter A.E. Sillevis-Smitt, Rob C. Hoeben
Last update: April 24, 2009